How it works

Zubsolv is a brand (trade) name for a sublingual tablet containing buprenorphine and naloxone that may be used to treat opioid addiction. Buprenorphine is an opioid (narcotic) with a distinct and complicated mechanism of action that involves partial binding to mu opioid receptors and total binding to kappa opioid receptors. Opioid receptors have three major effects: they reduce breathing (respiratory depression), they provide euphoria (intense happiness or excitement), and they reduce pain. Because of the way buprenorphine binds, it can fulfill opioid cravings without generating euphoria or substantial respiratory depression. Furthermore, while it is attached to opioid receptors, other opioids (such as heroin and oxycodone) are unable to bind.

It also lingers on the receptors for a longer period of time - roughly three days - making it an excellent candidate for usage in opioid addiction treatment programs. To dissuade abuse, this combo pill contains Naloxone. If drug users attempt to convert the pill into an injectable version, they will experience opioid withdrawal since naloxone is a highly potent mu opioid receptor blocker. When administered sublingually, naloxone has almost no additional impact. Zubsolv is a medication of the family known as combined opioid/opioid antagonists. It is also known as a narcotic analgesic combination.