Can Invokana be used alone or with other medications for diabetes?

Metformin is a first-line treatment for Type 2 diabetes. If your blood sugar remains high after taking metformin alone, you can combine it with Invokana. This combination of metformin and Invokana has been shown in studies to effectively lower blood sugar levels. In fact, canagliflozin and metformin are combined in single medications known as Invokamet (canagliflozin/metformin) and Invokamet XR (canagliflozin/metformin extended release).

Invokana has also been investigated as a supplement to other medications such as sulfonylureas and insulin. When combined with other diabetes medications, Invokana helped lower blood sugar levels in these studies. However, if you combine Invokana with insulin or other diabetes medications, your doctor will want to make sure your blood sugar doesn't drop too low.