Does Invokana interact with other medications?

Medicines that interact with Invokana may reduce its effect, shorten its duration of action, increase side effects, or have no effect when combined. An interaction between two medications does not always necessitate the discontinuation of one of them; however, it can. Consult your doctor about how to handle drug interactions.

The following are examples of medicines that may interact with Invokana:

• acetazolamide
• anticonvulsants such as phenytoin or phenobarbital
• antipsychotics, such as aripiprazole or clozapine
• beta-blockers, such as atenolol, labetalol, and metoprolol, may enhance the hypoglycemic effects
• ciprofloxacin or gatifloxacin
• corticosteroids, such as prednisone or cortisone
• digoxin
• diuretics, such as bumetanide, HCTZ, and bendroflumethiazide, which may enhance the potential for volume depletion
• HIV medications, such as amprenavir, atazanavir, fosamprenavir, and ritonavir
• hormones, such as ethinylestradiol and hydroxyprogesterone
• insulin (may increase risk of hypoglycemia)
• isoniazid
• rifampin
• other medications that affect blood sugar levels or are used for diabetes, such as glimepiride, or metformin.

Invokana may also intensify the harmful effects of drinking, resulting in flushing. Additionally, drinking alcohol may make diabetic ketoacidosis and hypoglycemia more likely.

Since SGLT2 inhibitors like Invokana raise urinary glucose excretion and can cause positive urine glucose tests, it is not recommended to use urine glucose tests to monitor glucose control in patients taking them. It is advisable to use alternative techniques for monitoring glucose management. There may also be interference with 1,5-AG tests.

Note that only commonly used drugs that may combine with Invokana are included in this list, which is not exhaustive. For a comprehensive catalog of interactions, consult the Invokana prescribing information.