Does Invokana cause any serious side effects?

Invokana can have more severe side effects, according to some research.

Invokana has been associated with:

• Higher risk of leg and foot amputations
• Extreme fluid loss
• Ketoacidosis, a serious issue of diabetes where blood sugar is dangerously high
• Serious kidney infections
• Necrotizing fasciitis (also called “flesh-eating bacteria”) in the genital area
• Bone fractures
• Low blood sugar (hypoglycemia) when used with certain medications