Itachi Uchiha
When discussing the top anime brothers, Itachi is frequently one of the first names that comes to mind. Itachi Uchiha was an Anbu Captain and a member of the Uchiha clan from Konohagakure. After killing every member of his clan, he later turned into a worldwide criminal, only saving his little brother Sasuke. After that, he joined the worldwide gang known as Akatsuki, whose activities frequently pitted him against Konoha and its ninja, particularly Sasuke, who wanted to exact revenge on his clan by killing Itachi.
Itachi was a devoted shinobi of Konohagakure to the very end, but after his death, it was revealed that his motivations were more nuanced than first thought and that his deeds had always been done for the benefit of his brother and community. Itachi seemed the furthest thing from a good brother in his first appearance in Naruto. He actually hit Sasuke and called him names. Itachi later lost the battle against Sasuke and passed away. Sasuke felt glad that he had been able to exact revenge on his clan's other members and parents.
Obito told Sasuke the truth about Itachi Uchiha shortly after their altercation. Itachi had been compelled to carry out the atrocity, the Akatsuki member explained to Sasuke, and he had only carried it out in order to save Sasuke. Itachi sacrificed everyone, even himself, in an effort to shield Sasuke from the dark.
Anime: Naruto