S-Adenosyl Methionine

Your body naturally produces a chemical called S-Adenosyl Methionine (SAMe). It helps produce and break down brain chemicals, such as serotonin, melatonin, and dopamine.

It could help some antidepressants work better and lessen the loss in brain function that depression patients experience. According to one study, patients who had previously not responded to therapy had a 14% higher chance of remission when SAMe was added to their antidepressant medication. More recently, one research discovered that SAMe could occasionally be just as helpful as certain antidepressant medications. However, there is no evidence that this supplement benefits people who don’t have depression.