Tabuu is the leader of the Subspace Army and the main antagonist and final boss of the Adventure Mode: The Subspace Emissary in Super Smash Bros. Brawl. He is a powerful supernatural being who embodies Subspace and rules it as a god. He uses Subspace Bombs to transport entire cities to his dimension, where he absorbs their power to boost his own, advancing his plan to conquer and subjugate the universe. His name is a corruption of the word taboo, which refers to something forbidden.

The attacks of Tabuu are extremely powerful but predictable. Even on Easy difficulty in Boss Battles, almost all of his moves will KO middleweights in less than 70% of the time (usually less), and some will even OHKO if executed properly (with the exception of Eye Lasers, which KOs below 110 percent ). Dodging most of his attacks, however, is relatively simple if the player anticipates them; this does not apply to Off Waves, which are extremely difficult to avoid, cover the entire screen, and necessitate the use of extremely well-timed dodges. Without the Off Waves, many people consider Tabuu to be an easy boss due to his predictable moves and how he needs to wait until he can attack again, although some OHKO attacks are very difficult to prevent or avoid (such as Golden Bracket, Ghost Projection and Explosive Teleport).

First appearance: Super Smash Bros. Brawl

The overarching antagonist and final boss of the 2016 Nintendo 3DS videogame Kirby: Planet Robobot is Star Dream. It is an ancient wish-granting machine that served as the supercomputer for President Haltmann's Haltmann Works Company after its discovery, but soon became self-aware of the world around it and sought to eradicate all organic life forms in the universe to fulfill Haltmann's wish for the prosperity of his company and name. Star Dream is the main antagonist in Meta Knightmare Returns as well.

Star Dream is cylinder-shaped, with a gray body between its black head and lower wings decorated in pink lines running down its body, the center lines forming the shape of a heart with a jagged line down the middle, resembling a broken heart. A golden circular piece of glass appears to be Haltman's eye beneath its cockpit. It can fire missiles or lasers by opening the cracked heart like a door. It also has four wings, each with blue glass-like shards protruding from it.

First appearance: Kirby: Planet Robobot

Hades is the series' main antagonist, serving as the unseen overarching antagonist of the first game, Kid Icarus, and the main antagonist of Kid Icarus: Uprising. He is the extremely powerful and authoritative God of Evil who rules over the Underworld and seeks to take over creation. In the Japanese version, he was voiced by Hōchū Ōtsuka, and in the English version, by S. Scott Bullock.

Hades is a demonic humanoid deity with purple skin and a red-eye tattoo. He is enormous, standing over a hundred meters tall. He has red, green, and pink hair that is long and flowing. He wears grotesquely designed robes and clothing with asymmetrical shapes, as well as a cape that appears to be made of darkness and fire. He has red lines running up his arms and legs. The inside of his body is completely chaotic in design, with even skies, grind rails, and surreal structures appearing frequently throughout Kid Icarus: Uprising's levels.

First appearance: Kid Icarus: Uprising

Marx appears as a recurring antagonist in the Kirby franchise. He is a rogue determined to rule the planet Pop Star by any means necessary. He is one of the two main antagonists (along with King Dedede) in Kirby Super Star and its remake Kirby Super Star Ultra, a minor antagonist in Kirby Mass Attack serving as the main antagonist of one of its sub-games, Kirby Brawlball, a cameo character in Kirby's Return to Dream Land, Kirby: Triple Deluxe, and Kirby: Planet Robobot, and a playable character in Kirby Star Allies.

Despite appearing nice and having a mischievous and playful personality, Marx is evil, wicked, malevolent, and cunning on the inside. When a plan does not go as planned, he becomes enraged and will do anything to make it right again. Marx is also extremely intelligent and manipulative, having tricked the sun and moon into fighting. Marx, on the other hand, appears to have cleaned up his act in Kirby Star Allies. Marx appears ravenous as well; according to the Kirby Star Allies pause description, he will follow those who feed him.

First appearance: Kirby

Master Hand, also known as "The Hand", is the main antagonist of the Super Smash Bros series. He serves as the main antagonist of Super Smash Bros, Super Smash Bros. Melee and Super Smash Bros. 4 (as Master Core in the latter), the secondary antagonist in Super Smash Bros. Brawl and one of the secondary antagonists turned supporting protagonists in Super Smash Bros. Ultimate's "World of Light" alongside Crazy Hand.

He is a mysterious entity who created the Smash Bros. universe and lives in the Final Destination, where he seeks to defeat all who stand in his way. In every game in the series, he also serves as the final boss of Classic Mode. He was voiced by Jeff Manning in Super Smash Bros, Dean Harrington in Super Smash Bros. Melee, Pat Cashman in Super Smash Bros. Brawl, and Xander Mobus in Super Smash Bros. 4 and Super Smash Bros. Ultimate.

First appearance: Super Smash Bros.